Dartford and Gravesham NHS Trust
Dartford Gravesham and Swanley CCG


Naldemedine is recommended as an option for treating opioid induced constipation in adults whose constipation has not adequately responded to laxatives. An inadequate response is defined as opioid-induced constipation symptoms of at least moderate severity in at least 1 of the 4 stool symptom domains (that is, incomplete bowel movement, hard stools, straining or false alarms) while taking at least 1 laxative class for at least 4 days during the prior 2 weeks.

For full details please see NICE TA 651 Naldemedine for treating opioid-induced constipation NICE guidance [TA651]

  • Preferred
  • On Formulary
  • Specialist Initiation
  • Hospital Use Only
  • Unlicensed Medicines